General medicine

3 articles in this category

SGLT2 Inhibitors Expand from Diabetes to Heart Failure and Kidney Disease as Foundational Cardiorenal Therapy

Words by Yuriy Poteshkin, MD, phD

Sodium-glucose cotransporter-2 (SGLT2) inhibitors emerged as foundational therapies for heart failure and chronic kidney disease regardless of diabetes status, with 2025 bringing definitive evidence...

Dec 31, 2025Read more

trends 2025SGLT2 inhibitorsheart failure

Personalized Hemodynamic Resuscitation Targeting Capillary Refill Time Improves Outcomes in Early Septic Shock

Words by Yuriy Poteshkin, MD, phD

The ANDROMEDA-SHOCK-2 trial provided high-quality evidence for personalized hemodynamic resuscitation guided by capillary refill time (CRT) in early septic shock. This multicenter trial across 19...

Dec 29, 2025Read more

septic shockhemodynamic resuscitationcapillary refill time

Dexmedetomidine Reduces Duration of ICU Delirium in Non-Intubated Critically Ill Patients

Words by Yuriy Poteshkin, MD, phD

The 4D randomized clinical trial demonstrated that continuous intravenous dexmedetomidine significantly reduced the combined burden of agitation, delirium, and need for intubation in non-intubated...

Dec 29, 2025Read more

dexmedetomidineICU deliriumhyperactive delirium